If any big money is involved, people will only buy what they know is good--or think they know is good.
Premium and/or hyped-up items still fetch premium cash on ebay. Many such items still sell for way too much in my opinion. "Good" vintage speakers and tubes, for example.
An approach that seems to work somewhat in the DIY sphere is to have a presence elsewhere on the web, eg on forums and a website and them use ebay as a point of sale mechanism.
That, plus a couple persuasive shills and you're good to go.
All told, selling finished speakers on the internet seems challenging. Better to sell KITS to the proper niche element, but then they would have to be relatively inexpensive.
I'm with Stuart on recognizing a need for chassis. I was looking for one last week. Ended up buying a Chinese flat pack aluminum job. Decent for $90 but lacks soul. There was a guy making aluminum chassis with hardwood sides and selling quite a few. He has since backed down to a few listings at higher prices. but he sold some.
Phenolic and perforated aluminum is a beautiful combo. Snag an engraving machine and make preamp chassis with 1/4" canvas phenolic faceplates with engraved legends and try to shift a few to somebody looking for a classy box.
Another plan that I think would work is to make repro cabinets for Altec drivers. There are way more drivers than cabinets. And the vintage cabs kinda suck in build quality and are mostly beat. Problem is that these won't be small and shipping will be a hassle, but there is a relatively upscale ready market for such items, audiophile and analog retro pro. In other words, you don't have to "sell" the item. People already want it.
Or make nice wood or high-tech phono headshells. High value to mass/volume item. Serious phono guys love to pay big money for trinkets. Pay somebody to CNC the parts if you don't have the machines. A good headshell can easily go for 100-300 bucks.
Wood tonearms are another genius option.
If you have a saw to rip plywood at an angle, I need a pair of large baffles cut for some badass field coil 18"s. Might have to take it as a flat pack kit so it will fit into my volvo wagon. You will never sell another pair after.
And I'll throw in some free expert philosophy and opinion on making money in audio. I've been doing it for 30 years and I say it is near-impossible, but there are some opportunities.